Assessment of causality between computer game playing and neuropsychiatric disorders: A bidirectional Mendelian randomization study.

ABSTRACT:

Introduction

Clinical studies indicated that computer games improve various aspects of physical function in different patients. However, research on the prevention of neuropsychiatric disorders through computer games is still insufficient. We utilized Mendelian randomization (MR) to assess whether there are the causal associations between playing computer games and schizophrenia (SCZ), bipolar disorder (BP), depression, panic disorder (PD), and Alzheimer's disease (AD).

Methods

We utilized summary statistics from genome-wide association studies of computer game playing and neuropsychiatric disorders. Inverse variance weighted (IVW) method was used as the primary analysis approach to perform bidirectional two-sample MR analysis on the data. Cochran Q test, MR-Egger intercept

SUBMITTER: Huo K 

PROVIDER: S-EPMC12041719 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature