Sex dependent correlation of spleen atrophy and behavior deficits induced by binge treatment with ethanol in rodent models.

ABSTRACT:

Objectives

During physical and psychosocial development, many adolescents engage in binge alcohol drinking. Ethanol (EtOH) is the key chemical in alcoholic beverages. EtOH intoxication impairs locomotor behaviors. We previously found that binge treatment with EtOH (BE) causes spleen atrophy, leading to immune dysregulation. With these premises, we hypothesized that BE-induced spleen atrophy is correlated with compromised locomotion and behaviors in adolescence.

Methods

We exposed F344 rats to either 3 days of BE (mimicking college drinking) or water following pubertal onset. 24 h following the last BE, we assessed behaviors using ANY-Maze, focusing on locomotor activity, freezing, and thigmotaxis, before spleen collection. Correlation analysis and Linear Regression analysis

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12041846 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature