Polydopamine-functionalized acellular fish scale scaffolds for accelerated bone tissue regeneration.

ABSTRACT: The complex microenvironment changes in the bone defect site are the main reason for its refractory treatment, including the significant increase in the level of reactive oxygen species (ROS) and inflammatory dysregulation. There is an urgent need to develop some bioactive materials that can regulate the microenvironment and promote bone regeneration. This study proposed a new strategy for designing bone tissue engineering scaffolds based on fish scales and developed a polydopamine-functionalized acellular fish scale scaffold (PDA-AFS). The results showed that PDA-AFS had excellent mechanical properties, special three-dimensional surface topography, and biodegradability. In vitro results showed that PDA-AFS had good biocompatibility and cell adhesion ability, could effectively reduc

SUBMITTER: Su S 

PROVIDER: S-EPMC12041853 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature