Silica-Immobilized Cyclic Urea Catalyst for the Reduction of Carboxylic Acids to Alcohols.

ABSTRACT: Catalytic reduction of carboxylic acids to the corresponding alcohols is a challenging but useful reaction. Since the conventional reduction methods such as hydrogenation and hydrosilylation largely rely on transition-metal catalysts, the development of heterogeneous organocatalysts for the reaction is an attractive research target. In this study, we achieved the reduction of benzoic acid derivatives to benzylic alcohols by hydrosilylation with a silica-immobilized cyclic urea catalyst followed by hydrolysis. The catalytic activity of immobilized cyclic urea was significantly higher than that of the free cyclic urea, silica supports, their physical mixture, or immobilized organocatalysts with different structures, such as cyclic carbonates and amines. Control experiments and Fourier transf

SUBMITTER: Hasegawa S 

PROVIDER: S-EPMC12041947 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature