Boosting the Host-Guest Binding by Programming the Curvature in Geodesic Nanoribbons.

ABSTRACT: The curvature of an aromatic system is an essential parameter that can be used to program the self-assembly and host-guest complementarity in geodesic polyarenes. However, the challenging synthesis of curved aromatics impedes exploration of the related effects on the binding properties. The design and synthesis of a polyarene with programmed curvature fitting to C₆₀ by a stepwise introduction of five-membered rings are presented to solve this challenge. Among several methods explored, the route utilizing cyclodehydrofluorination proved to be the most successful, in terms of the highest product yield. The binding studies suggest that fine-tuning the curvature in acyclic systems leads to a dramatic increase in affinity, embedding specific binding modes and selectivity, as revealed

SUBMITTER: Oshchepkov AS 

PROVIDER: S-EPMC12041955 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature