Activation and Allostery in a Fungal SAMHD1 Hydrolase: An Evolutionary Blueprint for dNTP Catabolism.

ABSTRACT: Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a metal-dependent hydrolase that plays key roles in dNTP homeostasis, antiretroviral defense, and regulation of various cancers in humans. Beyond mammals, SAMHD1 is also present in a wide range of eukaryotes, including invertebrates, plants, and human parasites. Although the specific mechanisms and biological significance of SAMHD1 in these organisms are not well understood, its functions are linked to essential processes such as photosynthesis, genome maintenance, and immune response. In this study, we bioinformatically mined the SAMHD1 superfamily and selected the ortholog from the mycorrhizal fungus Rhizophagus irregularis as a model system for both fungal and biochemically intractable plant SAMHD1s. Ri SAM

SUBMITTER: Pan L 

PROVIDER: S-EPMC12042053 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature