Linkage of Clinical Trial Data to Routinely Collected Data Sources: A Scoping Review.

ABSTRACT:

Importance

Patients who participate in clinical trials generate valuable routinely collected data (eg, medical records, electronic health records, claims databases, disease registries, or vital statistics) through their routine interactions with the health care system before, during, and after the trial. When this routinely collected data is linked at the participant level, it can supplement active data collection in the trial and provide deeper insights into the benefits, risks, and costs of treatments.

Objective

To review clinical trials linked to routinely collected data in various countries, identifying the use cases and designs of these linkage studies.

Evidence review

Research articles that reported the linkage of clinical trials to medical records, electronic h

SUBMITTER: NajafZadeh M 

PROVIDER: S-EPMC12042059 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature