Physical activity changes during midlife link to brain integrity and amyloid burden.

ABSTRACT:

Introduction

Evidence suggests that midlife physical activity may reduce Alzheimer's disease (AD) risk. In at-risk individuals, we investigated midlife physical activity changes in relation to AD-related pathologies.

Methods

We included 337 cognitively unimpaired adults with baseline and follow-up physical activity evaluations within 4.07 ± 0.84 years. We performed multiple regressions considering follow-up amyloid-PET burden and MRI-based medial temporal lobe cortical thickness as outcomes. Independent variables encompassed changes in adherence to World Health Organization (WHO)-recommended physical activity levels, activity amounts, and sedentary behavior (no activity reported).

Results

Remaining sedentary was associated with lower cortical thickness compared to doi

SUBMITTER: Akinci M 

PROVIDER: S-EPMC12042120 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature