Magnetic Resonance Imaging Characterization and Clinical Outcomes of Dilated and Arrhythmogenic Left Ventricular Cardiomyopathies.

ABSTRACT:

Background

Nondilated left ventricular cardiomyopathy (NDLVC) has been recently differentiated from dilated cardiomyopathy (DCM). A comprehensive characterization of these 2 entities using cardiac magnetic resonance (CMR) and genetic testing has never been performed.

Objectives

This study sought to provide a thorough characterization and assess clinical outcomes in a large multicenter cohort of patients with DCM and NDLVC.

Methods

A total of 462 patients with DCM (227) or NDLVC (235) with CMR data from 4 different referral centers were retrospectively analyzed. The study endpoint was a composite of sudden cardiac death or major ventricular arrhythmias.

Results

In comparison to DCM, NDLVC had a higher prevalence of pathogenic or likely pathogenic variants of arr

SUBMITTER: Castrichini M 

PROVIDER: S-EPMC12042165 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature