Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia.

ABSTRACT:

Background

Liver X receptors (LXRs) are expressed in placenta and may be associated with pre-eclampsia (PE). Oxysterols act as agonists for LXRs. We recently proposed a new blood pressure-regulating circuit with oxysterol 4β-hydroxycholesterol (4βHC) acting as a hypotensive factor via LXRs.

Materials and methods

This study investigated the association between maternal plasma 4βHC, blood pressure (BP) indices, placental expression of LXR target genes, and patient characteristics using data from the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort. Plasma samples of 144 women with PE and 38 healthy pregnant controls as well as 44 PE and 40 control placental samples were available. In addition, genetic data from the FinnGen project was utilized to explore th

SUBMITTER: Kaartinen L 

PROVIDER: S-EPMC12042236 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature