Carboxylic Acid Concentration in Downstream Bioprocessing Using High-Pressure Reverse Osmosis.

ABSTRACT: During the production of many bio-based chemicals from fermentation and enzymatic processes, product separations frequently represent the most expensive and energy-intensive unit operations in an integrated process, often due to the low concentrations of target bioproducts. In this study, we integrated high-pressure reverse osmosis (HPRO) to concentrate an exemplary fermentation product, butyric acid, prior to downstream extraction. Through both modeling and experimental measurements, we identified the major factors limiting the maximum achievable concentration factor (CF) of 4.0 for butyric acid concentration with an HPRO membrane compared to the 2.6-3.2 range for conventional reverse osmosis (RO) membranes. The resulting concentrated aqueous stream underwent liquid-liquid extraction with

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12042297 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature