Cold atmospheric plasma and skin wound healing: influence on microbial diversity and composition.

ABSTRACT:

Background

Skin wound healing presents a complex challenge, often compounded by the risk of infection. Cold atmospheric plasma (CAP) emerged as a novel therapeutic for reducing bacterial load and expediting wound healing. However, its effect on the wound microbiome remained unclear. This study aimed to characterize the microbiome of different types of wounds and determine whether CAP influenced microbial diversity.

Methods

Twenty-five patients (ten with acute, fifteen with chronic skin wounds) and ten healthy controls were enrolled. CAP was tailored to individual clinical conditions. Skin samples were collected before and after CAP, and microbiota composition was determined by 16 S ribosomal RNA sequencing.

Results

Microbial communities differed between acute and chro

SUBMITTER: Gao R 

PROVIDER: S-EPMC12042303 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature