The interaction effect between childhood trauma and negative events during adulthood on development and severity of irritable bowel syndrome.

ABSTRACT:

Background

Childhood trauma and negative events during adulthood were associated with the symptom severity of irritable bowel syndrome (IBS). However, the interaction effect of these negative events on IBS remains poorly understood.

Methods

70 healthy individuals who completed Childhood Trauma Questionnaire (CTQ) and Life Event Scale (LES) and 88 IBS patients, diagnosed based on the Rome IV criteria, who completed CTQ, LES, IBS-Quality of Life (IBS-QOL), and IBS-Severity Scoring System (IBS-SSS) were retrospectively included. Logistic and linear regression analyses were used to investigate the interaction effect between childhood trauma and negative events during adulthood on IBS.

Results

Female sex, childhood emotional abuse and neglect, and negative events during ad

SUBMITTER: Dong Z 

PROVIDER: S-EPMC12042304 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature