Individual and mixtures of PFAS during pregnancy are associated with maternal cardiometabolic outcomes during pregnancy.

ABSTRACT:

Introduction

Per- and polyfluoroalkyl substances (PFAS) are endocrine-disrupting chemicals and widespread environmental contaminants. PFAS cross the placental barrier and reach the developing fetus with potential impacts on many organ systems. There are no studies of PFAS in residents of central Arkansas despite reports of environmental contamination in the region. We aimed to quantify PFAS concentrations in repeated serum samples from participants living in central Arkansas and to investigate relationships with maternal cardiometabolic health during pregnancy.

Methods

Participants were enrolled during early pregnancy in a longitudinal study (NCT01131117) from 2010 to 2014. PFAS concentrations were measured in serum from each trimester (first trimester n = 282, second trimes

SUBMITTER: Sims CR 

PROVIDER: S-EPMC12042336 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature