Whole-genome sequencing reveals patterns of runs of homozygosity underlying genetic diversity and selection in domestic rabbits.

ABSTRACT:

Background

Runs of homozygosity (ROH) are continuous segments of homozygous genotypes inherited from both parental lineages. These segments arise due to the transmission of identical haplotypes. The genome-wide patterns and hotspot regions of ROH provide valuable insights into genetic diversity, demographic history, and selection trends. In this study, we analyzed whole-genome resequencing data from 117 rabbits to identify ROH patterns and inbreeding level across eleven rabbit breeds, including seven Chinese indigenous breeds and four exotic breeds, and to uncover selective signatures based on ROH islands.

Results

We detected a total of 31,429 ROHs across the autosomes of all breeds, with the number of ROHs (N_ROH) per breed ranging from 1316 to 7476. The mean sum

SUBMITTER: Ping X 

PROVIDER: S-EPMC12042440 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature