Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases.

ABSTRACT: Non-coding 886 (nc886, vtRNA2-1) is a polymorphically imprinted gene. The methylation status of this locus has been shown to be associated with periconceptional conditions, and both the methylation status and the levels of nc886 RNAs have been shown to associate with later-life health traits. We have previously shown that nc886 RNA levels are associated not only with the methylation status of the locus, but also with a genetic polymorphism upstream from the locus. In this study, we describe the genetic and epigenetic regulators that predict lifelong nc886 RNA levels, as well as their association with cardiometabolic disease (CMD) risk factors and events. We utilised six population cohorts and one CMD cohort comprising 9058 individuals in total. The association of nc886 RNA levels, as predi

SUBMITTER: Rajic S 

PROVIDER: S-EPMC12042507 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature