Immunoglobulin gene loci structure and diversity of raccoon dog (Nyctereutes procyonoides).

ABSTRACT: In this study, we analyzed the loci structure of raccoon dog genes using a comparative genomics approach. We investigated the mechanism of expression diversity and its preference using the Next-generation sequencing. The results indicated that the raccoon dog gene loci structure were similar to that of most mammals, with a relative abundance of V(D)J genes, which ensures its expression diversity. We identified the following potentially functional genes: 7 VH genes, 6 Vκ genes, 23 Vλ genes, 24 DH genes, 5 JH genes, 4 Jκ genes, and 6 Jλ genes, arranged in a manner similar to that of other mammals. Analysis of the raccoon dog expression diversity mechanism showed that raccoon dog have a strong preference for the use of V genes, and the same was true for DH genes. The main modes of expression

SUBMITTER: Yi X 

PROVIDER: S-EPMC12042606 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature