Pediatric adrenocortical carcinoma complicated by uric acid nephrolithiasis: a unique case report.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is an exceedingly rare malignancy in children, typically presenting with Cushing's syndrome due to excessive hormone secretion. The occurrence of uric acid nephrolithiasis in pediatric ACC patients is exceptionally uncommon.

Case presentation

We report the case of a 5-year-old boy who exhibited symptoms of Cushing's syndrome over a period of 10 months, including rapid weight gain, moon face, and increased chest and back hair growth. Laboratory tests revealed elevated cortisol, 17-hydroxyprogesterone, and testosterone levels. Imaging studies identified a 6.6 × 5.6 cm mass in the left adrenal gland, which was confirmed as ACC through biopsy and immunohistochemistry. One day prior to the scheduled adrenalectomy, the patient developed re

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12042628 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature