Effect of the vitamin D supplementation on clinical outcomes and inflammatory status in COVID-19 patients: an umbrella review.

ABSTRACT:

Introduction

The role of vitamin D supplementation in modulating clinical outcomes and inflammatory responses in COVID- 19 patients has garnered significant interest. This umbrella review consolidates current evidence to evaluate the association between vitamin D supplementation and COVID- 19-related outcomes.

Methods

A comprehensive search was conducted across multiple databases to identify relevant systematic reviews and meta-analyses. Studies assessing the impact of vitamin D supplementation on disease severity, mortality, hospitalization, and inflammatory markers in COVID- 19 patients were included. Methodological quality was assessed using standardized tools.

Results

The findings suggest that vitamin D supplementation may be associated with reduced mortality and

SUBMITTER: Jafari-Vayghan H 

PROVIDER: S-EPMC12042636 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature