A novel staging system of cardiac damage in aortic stenosis based on multi-chamber myocardial deformation.

ABSTRACT:

Aims

This study evaluates whether multi-chamber myocardial deformation analysis using speckle tracking echocardiography (STE) can enhance validated current staging systems and improve risk stratification for patients with moderate-to-severe aortic stenosis (AS).

Methods and results

We reanalysed 2D, Doppler, and STE data obtained from two cohorts: derivation (654 patients, median age: 82 years; 51% men) and validation (237 patients, median age: 77 years; 55% men) with at least moderate AS (aortic valve area < 1.5 cm2). The receiver operator characteristic curve analysis identified optimal cut-off values linked to outcomes: 15% for left ventricular global longitudinal strain (LVGLS), 13% for peak atrial longitudinal strain (PALS), and 19% for right ventricular free-wall strai

SUBMITTER: Tomaselli M 

PROVIDER: S-EPMC12042747 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature