Incremental value of multiparametric cardiac magnetic resonance imaging for non-invasive identification of significant acute cardiac allograft rejection: a prospective and biopsy-proven study.

ABSTRACT:

Aims

This study aimed to evaluate the association between cardiac magnetic resonance imaging (CMR) multiparameters and significant acute cardiac allograft rejection (SR), and assess the incremental value of CMR multiparameters over conventional serum examinations for identifying SR.

Methods and results

Heart transplantation (HTx) recipients with endomyocardial biopsy and healthy controls were prospectively recruited for CMR assessment. CMR feature tracking was performed to evaluate the left ventricular (LV) global strain in all three directions. The last serum examinations including N-terminal pro-brain natriuretic peptide (NT-proBNP) before anti-rejection therapy were recorded. Participants were divided into three groups: control, SR [acute cellular rejection grade ≥ 2R and

SUBMITTER: Zhou P 

PROVIDER: S-EPMC12042751 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature