Urinary eicosanoid levels in early life and risk of atopic disease in childhood.

ABSTRACT:

Background

Eicosanoids are lipid mediators including thromboxanes (TXs), prostaglandins (PGs), and leukotrienes with a pathophysiological role in established atopic disease. However, their role in the inception of disease is unclear. This study aimed to investigate the association between urinary eicosanoids in early life and development of atopic disease.

Methods

This study quantified the levels of 21 eicosanoids in urine from children from the COPSAC₂₀₁₀ (Copenhagen Prospective Studies on Asthma in Childhood 2010) (age 1 year, n = 450) and VDAART (Vitamin D Antenatal Asthma Reduction Trial) (age 3 years, n = 575) mother-child cohorts and analyzed the associations with development of wheeze/asthma, atopic dermatitis, and biomarkers of type-2 inflammation, applyin

SUBMITTER: Chen L 

PROVIDER: S-EPMC12042789 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature