Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.

ABSTRACT: The role played by the transient receptor potential vanilloid 1 (TRPV1) channel on the thin fibre afferents evoking the exercise pressor reflex is controversial. To shed light on this controversy, we compared the exercise pressor reflex between newly developed TRPV1^+/+ , TRPV1^+/- and TRPV1^-/- rats. Carotid arterial injection of capsaicin (0.5 μg), evoked significant pressor responses in TRPV1^+/+ and TRPV1^+/- rats, but not in TRPV1^-/- rats. In acutely isolated dorsal root ganglion neurons innervating the gastrocnemius muscles, capsaicin evoked inward currents in neurons isolated from TRPV1^+/+ and TRPV1^+/- rats but not in neurons isolated from TRPV1^-/- rats. The reflex was evoked by stimulating

SUBMITTER: Anselmi L 

PROVIDER: S-EPMC12042824 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature