The Effects of Prescribed Medications on Depressive Symptoms and Neurocognitive Performance in People With HIV.

ABSTRACT:

Background

Alterations in brain function and structure, such as depression and neurocognitive impairment, continue to occur in people with human immunodeficiency virus (HIV, PWH) taking suppressive antiretroviral therapy (ART). The lifespan of PWH has improved but the healthspan remains worse than people without HIV, in part because of aging-related diseases. As a result, polypharmacy is common and increases the risk of drug-drug interactions and adverse reactions.

Methods

This cross-sectional project investigated the relationship between 7 medication-related metrics (including anticholinergic burden), depressive symptoms, and neurocognitive performance in 491 PWH at a single center in the United States. All participants were taking ART and had plasma HIV RNA ≤ 200 copies/mL

SUBMITTER: Kamkwalala AR 

PROVIDER: S-EPMC12043063 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature