High resolution diffusion imaging in the unfixed post-mortem infant brain at 7T.

ABSTRACT: Diffusion MRI of the infant brain allows investigation of the organizational structure of maturing fibers during brain development. Post-mortem imaging has the potential to achieve high resolution by using long scan times, enabling precise assessment of small structures. Technical development for post-mortem diffusion MRI has primarily focused on scanning of fixed tissue, which is robust to effects like temperature drift that can cause unfixed tissue to degrade. The ability to scan unfixed tissue in the intact body would enable post-mortem studies without organ donation, but poses new technical challenges. This paper describes our approach to scan setup, protocol optimization, and tissue protection in the context of the Developing Human Connectome Project (dHCP) of neonates. A major consid

SUBMITTER: Wu W 

PROVIDER: S-EPMC12043270 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature