STING agonist-based ER-targeting molecules boost antigen cross-presentation.

ABSTRACT: CD8⁺ T cell immune responses are critical for combating infectious diseases and tumours^1-3. Antigen cross-presentation, primarily occurring at the endoplasmic reticulum (ER) of dendritic cells, is essential for protein-based vaccines to induce CD8⁺ T cell responses⁴. Current efforts have focused on antigen delivery at the tissue and cellular levels, whereas subcellular delivery has been limited to facilitating antigen escape from lysosomes into the cytosol. In the absence of a small-sized high-affinity ER-targeting molecule, the importance of the 'last mile' from the cytosol to the ER remains elusive. Here we developed stimulator of interferon genes (STING) agonist-based ER-targeting molecules (SABER), which effectively deliver antigens to the ER

SUBMITTER: Wang X 

PROVIDER: S-EPMC12043507 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature