Delineating circulating lymphocyte subsets in the transition from gout remission to recurrence.

ABSTRACT:

Objectives

Lymphocytes and their subsets are implicated in both the onset and remission of gout. However, the specific roles in gout recurrence and complete remission remain unclear. This study aimed to characterize lymphocyte immunophenotypes across different stages of gout and developed a predictive model for remission and recurrence of gout.

Methods

Plasma levels of 75 lymphocyte immunophenotypes were determined using multiplex flow cytometry in patients with acute gout flare (AG, n=78), gout remission (RG, n=63), and healthy controls (NC, n=66). Lymphocyte immunophenotyping candidates and significant clinical parameters were subjected to LASSO regression for conducting a predictive model.

Results

Significant variations in lymphocyte profiles were identified among

SUBMITTER: Yu H 

PROVIDER: S-EPMC12043595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature