Bee venom ameliorates gentamicin-induced kidney injury by restoring renal aquaporins and enhancing antioxidant and anti-inflammatory activities in rats.

ABSTRACT:

Introduction

Gentamicin (GM) is a frequently used aminoglycoside for managing serious illnesses; nonetheless, renal complications limit its use. Bee venom (BV) is a biological toxin that exhibits anti-inflammatory and antioxidant activities. This study was designed to explore the mitigating effect of BV remediation on GM induced renal injury.

Methods

Twenty male rats were divided into four groups (five rats each), namely, control (saline subcutaneously); BV group (1 mg/kg S/C twice weekly for 1 month); GM group (100 mg/kg i. p. for 1 week); and GM-BV group (the same aforementioned dosages of GM and BV, with GM administered in the last week for 4 weeks).

Results and discussion

BV mitigated the GM-inflicted kidney damage, as evidenced by a substantial improvement in the

SUBMITTER: Abdelrahaman D 

PROVIDER: S-EPMC12043641 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature