Targeting PCNA/PARP1 axis inhibits the malignant progression of hepatocellular carcinoma.

ABSTRACT:

Introduction

Proliferating cell nuclear antigen (PCNA) is associated with the proliferation and recurrence of various cancers, and its high expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients. However, the mechanistic role of PCNA in HCC progression remains poorly understood. This study aimed to investigate how PCNA regulates DNA damage repair and cell cycle progression in HCC, with a focus on its interaction with poly (ADP-ribose) polymerase 1 (PARP1) and therapeutic implications.

Methods

PCNA was targeted genetically and pharmacologically in HCC cells to assess its effects on DNA damage repair and cell cycle arrest. Protein-protein interactions between PCNA and PARP1 were validated through co-immunoprecipitation and functional assays. Th

SUBMITTER: Li J 

PROVIDER: S-EPMC12043649 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature