Concomitant autoimmunity and late cancers in adult-onset immunodeficiency due to neutralizing anti-IFN-γ autoantibodies.

ABSTRACT:

Background

Opportunistic intramacrophagic infections are well-characterized in adult-onset immunodeficiency associated with neutralizing anti-IFN-γ autoantibodies (nAIGA).

Objective

Concomitant autoimmune and neoplastic diseases are rarely described.

Methods

This study included 50 patients diagnosed with adult-onset immunodeficiency due to nAIGA between 2014-2024. Thirty-three were retrospectively included before January 2022, and 17 out of 295 screened patients were enrolled prospectively since January 2022. Ten patients were excluded due to missing records. All patients had regular follow-ups; anti-IFN-γ titers, autoimmune markers and cancer survey were conducted according to the primary physician's evaluation.

Results

The median age at diagnosis of adult-ons

SUBMITTER: Tsai WT 

PROVIDER: S-EPMC12043703 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature