Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease.

ABSTRACT:

Background

Gait disturbance is a prevalent characteristic of cerebral small vessel disease (CSVD), yet the underlying mechanisms remain largely unclear.

Aimes

To test the hypothesis that enlarged perivascular spaces in the basal ganglia (BG-EPVS) are related to gait performance in individuals with CSVD and the elderly.

Methods

This cross-sectional study included 138 CSVD patients and 62 healthy elderly controls who underwent quantitative gait analysis. Neuroimaging markers, including BG-EPVS, white matter hyperintensities (WMH), lacunes, and cerebral microbleeds (CMB), were assessed using MRI. Principal component analysis (PCA) was used to reduce the dimensionality of multiple gait indicators. Linear regression models were employed to examine the relationship between

SUBMITTER: Yang S 

PROVIDER: S-EPMC12043758 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature