Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity.

ABSTRACT:

Rationale

In 2018, the International Classification of Diseases (ICD-11) classified Gaming Disorder (GD) as a mental disorder. GD mainly occurs among adolescents, who, after developing addiction, show psychopathological traits, such as social anxiety, depression, social isolation, and attention deficit. However, the different studies conducted in humans so far show several limitations, such as the lack of demographic heterogeneity and equal representation of age, differences in the type of game and in the follow-up period. Furthermore, at present, no animal models specific to GD are available.

Objectives

To address the lack of an experimental model for GD, in the present work, we proposed a new GD rat model to investigate some peculiar tracts of the disorder.

Methods

SUBMITTER: Casile A 

PROVIDER: S-EPMC12043766 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature