Altered miRNA expression in duodenal tissue of celiac patients and the impact of a gluten-free diet: a preliminary study.

ABSTRACT:

Background

MicroRNAs (miRNAs) are crucial regulators of gene expression, impacting a wide range of biological processes. Their dysregulation can result in pathological changes and contribute to the development of various disorders. This study aims to evaluate the expression of selected miRNAs in duodenal tissue of paediatric patients with active celiac disease (CD), investigate the role of dysregulated miRNAs in disease pathogenesis and assess the changes in their expression profile in response to a gluten-free diet (GFD).

Methods and results

The study included newly diagnosed celiac patients (n = 20), celiac patients adhering to a GFD (n = 17) and a control group (n = 29). The miRNA expression in duodenal samples was quantified by real-time PCR. Dysregulated miRNAs were ana

SUBMITTER: Kolkova Z 

PROVIDER: S-EPMC12043776 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature