Association of TERT promoter mutation with oral squamous cell carcinoma: a systematic review and meta-analysis.

ABSTRACT: The telomerase reverse transcriptase (TERT) promoter mutations have been linked to the prognosis and survival of several cancers; however, it is still debatable in case of oral squamous cell carcinoma. The exact reason for it is currently unknown. However, considering its role in cell survival and proliferation it is imperative to evaluate the association between TERT promoter mutations and OSCC. The systematic review and meta-analysis were carried out to gather evidence for TERT promotor mutation in OSCC. Electronic databases along with grey literature were searched for relevant studies. We used fixed- or random-effect models to calculate pooled proportion, estimated odds ratios or standardized mean differences, and corresponding 95% confidence intervals (CIs). We included 13 eligible stu

SUBMITTER: Yuwanati M 

PROVIDER: S-EPMC12043803 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature