The diagnostic value of advanced tracer kinetic models in evaluating high grade gliomas recurrence and treatment response using dynamic contrast-enhanced MRI.

ABSTRACT:

Background

The purpose of this study was to investigate the diagnostic value of advanced tracer kinetic models (TKMs) in differentiating HGGs recurrence and treatment response.

Methods

A total of 52 HGGs were included. DCE images were analyzed using the following TKMs: distributed parameter (DP), tissue homogeneity (TH), Brix's two-compartment (Brix) and extended-Tofts model (ETM), yielding the following parameters: cerebral blood flow (CBF), mean transit time (MTT), plasma volume (V_p), extravascular volume (V_e), vascular permeability (PS) and first-pass extraction ratio (E) in advanced TKMs (DP, TH and Brix); K^trans, V_e, V_p and K_ep in ETM. Two delineation methods were conducted (routine scans and parameter he

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12043873 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature