Reappraisal of IgG subclass deficiencies: a retrospective comparative cohort study.

ABSTRACT:

Objective

The aim of the present study was to investigate the clinical spectrum of IgG subclass deficiencies (IgGSDs) and assess the relative clinical significance of diagnosing each specific IgGSD disorder as compared to the common variable immunodeficiency (CVID).

Methods

The clinical spectrum and immunological findings from 96 patients, diagnosed with diverse IgGSDs, were retrospectively evaluated. Specific IgGSDs were compared with each other and a cohort of 270 patients with CVID.

Results

In comparison to CVID, recurrent lower respiratory tract infections (LRTIs) and bronchiectasis were rarer in IgGSDs, while recurrent mucocutaneous herpes simplex virus reactivations were more common. With respect to autoimmunity, IgGSDs were associated with arthritis, while auto

SUBMITTER: Dogru D 

PROVIDER: S-EPMC12043879 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature