Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway.

ABSTRACT:

Introduction

Fatty acid metabolism plays a crucial role in regulating airway inflammation through the synthesis of lipid mediators. We have previously demonstrated that a 12/15-lipoxygenase (12/15-LOX or Alox15)-derived mediator attenuates IL-33-induced eosinophilic airway inflammation in mice. However, the cellular sources of these mediators remain unclear.

Methods

To identify the cellular sources, we used several cell type-specific conditional 12/15-LOX-deficient mice.

Results

We found that eosinophils and pleural macrophages were the major 12/15-LOX-expressing cell types responsible for attenuating airway inflammation. Eosinophils were the major population of 12/15-LOX-expressing cells found in inflamed lung tissue. In addition, pleural macrophages were the major p

SUBMITTER: Ito E 

PROVIDER: S-EPMC12043891 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature