Integrated bioinformatics analysis of biomarkers and pathways to explore the mechanisms and molecular targets related to allergic rhinitis and pyroptosis.

ABSTRACT: Allergic rhinitis (AR) is a condition with a rising global prevalence, though its specific pathogenic mechanisms remain elusive. Several studies have indicated that pyroptosis is one of the key mechanisms in the pathogenesis of AR. However, no research has investigated the molecular targets of pyroptosis in the context of AR. Our study endeavored to identify common biomarkers and mechanisms that could offer insights into the prevention of AR progression and novel therapeutic targets. Data from the Gene Expression Omnibus (GEO) database, including GSE51392, GSE43523, and GSE44037, were downloaded and analyzed through weighted gene co-expression network analysis (WGCNA), Least Absolute Shrinkage and Selection Operator (LASSO), and random forest (RF) analysis to identify key intersecting gene

SUBMITTER: You M 

PROVIDER: S-EPMC12043997 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature