Whole-body and site specific [¹⁸F]FDG uptake patterns on PET/CT have limited value in differentiating between polymyalgia rheumatica and other inflammatory diseases: two cohorts of treatment-naive suspected polymyalgia rheumatica.

ABSTRACT:

Background

It has been hypothesized that 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) positron emission tomography (PET) computed tomography (CT) can distinguish polymyalgia rheumatica (PMR) from non-PMR patients based on the [¹⁸F]FDG-uptake patterns. Nevertheless, a comprehensive assessment of whole-body [¹⁸F]FDG-patterns across all uptaking musculoskeletal sites, as well as site-specific [¹⁸F]FDG-uptake patterns, has not been conducted. Therefore, this study aimed to investigate both the overall whole-body [¹⁸F]FDG-uptake patterns and the specific uptake patterns at individual sites in patients suspected of having PMR.

Methods

Two distinct cohorts of patients with suspected PMR from Denmark and the Netherlands

SUBMITTER: Nielsen AW 

PROVIDER: S-EPMC12044134 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature