The mechanism of maternal inheritance of glycolipid metabolism disorder in a zebrafish model of type 2 diabetes.

ABSTRACT: In recent years, the number of people with type 2 diabetes mellitus (T2DM) has been increasing, and there is obvious familial aggregation of T2DM. Pregestational and gestational diabetes mellitus are the most common chronic conditions during pregnancy. However, the mechanism by which maternal preconception hyperglycaemia affects glucolipid metabolism in the offspring is not fully understood. Zebrafish have been widely used to construct T2DM models. In this study, we established a successful T2DM model of female zebrafish by immersing them in a 2% glucose solution for 28 days. The results showed that female zebrafish in the T2DM group exhibited damage to the ovaries and livers. Fasting blood glucose, insulin, cholesterol and triglycerides were increased in the T2DM group compared to the con

SUBMITTER: Yang F 

PROVIDER: S-EPMC12044153 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature