Systemic hormone therapy and dementia: A nested case-control and co-twin control study.

ABSTRACT:

Objective

The effect of systemic hormone therapy (HT) on dementia risk is unclear. Our aim was to investigate the association between HT and dementia.

Study design

This register-based study consists of a nested case-control study and a co-twin control design, which controls for familial confounding, including shared genetics.

Main outcome measures

Through Danish national registries from 1995 to 2011, we identified: a) 2700 female singletons with incident dementia and 13,492 matched controls; b) 288 female twins with incident dementia and co-twins without dementia. Data on HT and education were retrieved, and analyses were performed using conditional logistic regression and McNemar's χ²-test. HT use decreased dramatically after the Women's Health Initiative

SUBMITTER: Lokkegaard LE 

PROVIDER: S-EPMC12044222 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature