Postexposure Antimicrobial Drug Therapy in Goats Infected with Burkholderia pseudomallei.

ABSTRACT: Infection with Burkholderia pseudomallei, the causative agent of melioidosis, occurs by exposure to the organism in soil or water. There is concern for B. pseudomallei use as a potential bioweapon and as an exposure hazard in diagnostic laboratories processing samples or cultures containing the bacterium. The optimal strategies for treatment and postexposure prophylaxis are inadequately developed. This study used goats to evaluate 3 antimicrobial drug treatment regimens for postexposure therapy because they are a species naturally susceptible to B. pseudomallei infection. Goats were infected by percutaneous inoculation, and antimicrobial drug therapies were initiated 48 hours later. Widespread infection with abscess formation in multiple organs developed in untreated goats and goats treate

SUBMITTER: Bowen RA 

PROVIDER: S-EPMC12044257 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature