Screening Biomarkers and Risk Factors for COVID-19 Progression in a Border Population Between Brazil-Bolivia.

ABSTRACT:

Background

The performance and genetic role in host response delineate investigative points of polymorphisms as potential biomarkers in viral infections.

Methods

Thus, this research aimed to map biomarkers and risk factors in the severity of COVID-19 in individuals in Western Amazon (n = 243).

Results

Patients aged 40 to 59 years showed an association with clinical progression (P = .003), also evidencing the relationship for individuals >60 years (P < .001), besides the non-vaccination influenced the pathology (P = .023). qPCR for human genotyping of the targets rs2070788, rs4702, rs76635825, rs540856718, rs35803318, rs12979860, and rs16899066, as well as for gene expression of ACE2, HLA-A, HLA-B, IFNL-3/2, IL-6, and TMPRSS2 was used. The rs129798

SUBMITTER: Passos-Silva AM 

PROVIDER: S-EPMC12044272 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature