A structural element within the 5'UTR of β-catenin mRNA modulates its translation under hypoxia.

ABSTRACT: Tight regulation of translation initiation is crucial for cellular adaptation to environmental changes. Stress conditions like hypoxia trigger translational reprogramming of mRNAs encoding proteins essential for stress recovery and cell survival. Recent studies highlight alternative translation initiation pathways based on specific motifs in mRNA 5' untranslated regions (5'UTRs). Notably, β-catenin is of particular interest since maintaining its translation promotes cancer cell persistence and plasticity. β-Catenin, an oncogenic protein, plays a key role in Wnt signalling. Besides dysregulation of the β-catenin/Wnt pathway, chemotherapy-induced hypoxia leads to abnormal nuclear β-catenin accumulation, modulating gene expression linked to cancer progression and metastasis. However, the mech

SUBMITTER: D'Agostino M 

PROVIDER: S-EPMC12044334 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature