Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naive nonhuman primates define neural vulnerability for future risky ethanol consumption.

ABSTRACT: Alcohol use disorder (AUD) is a highly prevalent, complex, multifactorial and heterogeneous disorder, with 11 % and 30 % of adults meeting criteria for past-year and lifetime AUD, respectively. Identification of the molecular mechanisms underlying risk for AUD would facilitate effective deployment of personalized interventions. Studies using rhesus monkeys and rats, have demonstrated that individuals with low cognitive flexibility and a predisposition towards habitual behaviors show an increased risk for future heavy drinking. Further, low cognitive flexibility is associated with reduced dorsolateral prefrontal cortex (dlPFC) function in rhesus monkeys. To explore the underlying unique molecular signatures that increase risk for chronic heavy drinking, a genome-wide DNA methylation (DNAm)

SUBMITTER: Cervera-Juanes RP 

PROVIDER: S-EPMC12044430 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature