Acute Alcohol-Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography.

ABSTRACT:

Background

Alcohol consumption at clinically relevant doses alters brain glutamate release. However, few techniques exist to measure these changes in humans. The metabotropic glutamate receptor 5 (mGluR5) PET radioligand [¹¹C]ABP688 is sensitive to acute alcohol in rodents, possibly mediated by alcohol effects on glutamate release. This study aimed to determine the sensitivity of [¹¹C]ABP688 PET to an acute alcohol challenge in humans.

Methods

Eight social drinkers (25-42 years; 5 females) with a recent drinking occasion achieving a blood alcohol level (BAL) > 80 mg/dL were recruited. All participants underwent a 90-min dynamic baseline [¹¹C]ABP688 PET scan. Two weeks later (range: 7-29 days), participants completed an oral laboratory alcohol

SUBMITTER: Raval NR 

PROVIDER: S-EPMC12044519 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature