PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease.

ABSTRACT: Alcohol-associated liver disease (ALD) is one of the major chronic liver diseases and despite the dire clinical needs and extensive research efforts, no effective therapies are available for late-stages of ALD except for liver transplantation. Adipose tissue dysfunction has been implicated in the progression of ALD. Furthermore, it has been previously suggested that thermogenic fat can be activated after alcohol consumption. In this study, increased thermogenic gene expression was detected in both classical brown adipose tissue and beige adipocytes in mice that were given alcohol challenges even when housed at thermoneutrality. In particular, higher expression level of Prdm16, the key transcriptional co-component for beige fat function, was observed in the subcutaneous fat of mice after al

SUBMITTER: Liu S 

PROVIDER: S-EPMC12044534 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature