Postoperative Outcomes Among Sodium-Glucose Cotransporter 2 Inhibitor Users.

ABSTRACT:

Importance

Case reports and small retrospective studies have suggested that there is an increased risk of postoperative euglycemic ketoacidosis (eKA) and acute kidney injury (AKI) among patients using sodium-glucose cotransporter 2 inhibitors (SGLT2i) preoperatively. However, there has not been a representative assessment of the risks of these agents among patients undergoing surgery.

Objective

To evaluate the risk of postoperative eKA, AKI, and mortality within 30 days after surgery among preoperative long-term SGLT2i users compared with nonusers.

Design, settings, and participants

This is a multicenter, propensity-matched, retrospective case-control study from the Veterans Affairs Health Care System (VAHCS) National Registry performed from January 1, 2014, to Decemb

SUBMITTER: Tallarico RT 

PROVIDER: S-EPMC12044541 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature