Prognosis of isolated tumor cells and use of molecular classification in early stage endometrioid endometrial cancer.

ABSTRACT:

Objective

We assessed the prognosis and molecular subtypes of early stage endometrioid endometrial cancer with isolated tumor cells within sentinel lymph nodes (SLNs) compared with node negative disease.

Methods

Patients diagnosed with stage IA, IB, or II endometrioid endometrial cancer and primary surgical management were identified from January 1, 2007 to December 31, 2019. All SLNs underwent ultrastaging according to the institutional protocol. Patients with cytokeratin positive cells, micrometastases, and macrometastases were excluded. Clinical, pathology, and molecular subtype data were reviewed.

Results

Overall, 1214 patients with early stage endometrioid endometrial cancer met the inclusion criteria, of whom 1089 (90%) had node negative disease and 125 (10%) ha

SUBMITTER: Rios-Doria E 

PROVIDER: S-EPMC12044596 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature