Interfacial Interactions between Neural Tracing Lectin-Gold Nanoparticle Conjugate and Cell Membrane Glycoproteins.

ABSTRACT: The use of neural tracers as targeting molecules for drug delivery has been previously established as a novel and efficient method of neural drug delivery. The wheat germ agglutinin-horseradish peroxidase conjugate (WGAHRP) is a common neural tracer, which has been used extensively to decipher neural pathways in vertebrates. It has been widely reported to bind to cell surfaces and be transported in a retrograde fashion (from synapses toward the cell body) via dynein motors along microtubules within axons and transynaptically between neurons. Here we report on the differential binding between WGAHRP and gold-conjugated WGAHRP (AuNP-WGAHRP) to the glycoprotein profiles extracted from two neuronal cell lines and one skeletal muscle cell line, as well as the binding kinetics to heparin. From p

SUBMITTER: Yong J 

PROVIDER: S-EPMC12044695 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature